A Guide to Analysis of Chiral Compounds by GC #59889

Analysis of Chiral Compounds by GC Chiral Catalog 6p 35k per p

Introduction . . . 1-2
What are Chiral ompounds . . . 3

Any carbon atom that is bonded to four different groups is termed a chiral or an assymetric carbon. Molecules containing one or more of these carbon centres are considered chiral molecules. Chiral centers can exist in two forms called enantimmers. These two forms are non-superimposible mirror images of each other, but both have similar properties

What is Chiral Chromatography . . . 4

Chiral chromatography is the separation of enantiomeric compounds. Common liquid stationary phases do not possess adequate selectivity for enantiomeric separation. Addition of derivatised cyclodextrin macromolecules to common GC stationary phases creates capillary columns with the ability to separate many enantiomers

• Rt-betaDEXsm
• Rt-betaDEXse
• Rt-betaDEXsp
• Rt-betaDEXsa
• Rt-betaDEXcst
• Rt-betaDEXm

Applications in . . .
biomedical,
pharmaceutical,
food flavor analysis

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Restek's Chiral Columns Offer Unique Selectivity . . . 5-9
Optimisation of Chiral Separartions . . . 10-13
Chiral Specific Applications of Essential Oils, Flavors and Pharmaceuticals . . . 14-23

• Essential Oils : Lemon; Rosemary, Peppermint; Spearmint; Lavender; Germanium, Rose Oils
• Flavors : Bergamot; Peach; Raspberry
• Drugs : Fenfluramine; Barbiturates; Amphetamines

Stereochemical properties of chiral drugs have been found in many instances tom be the controlling factor concerning activity. One enantiomer may provide a biological function and the other may be inactive or may exhibit another functionality, which could result in side effects

Product List . . . 23

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